First detection | PANGO Lineages nomenclature system | Other names | Notable mutations | Evidence of clinical changes[note 1] | Spread | Ref. | |||
---|---|---|---|---|---|---|---|---|---|
Location | Date | Transmissibility | Virulence | Antigenicity | |||||
Nigeria | Aug 2020 | B.1.1.207 | P681H | -- | -- | -- | Localized | [2] | |
United Kingdom | Sep 2020 | B.1.1.7 | VOC-202012/01, 20I/501Y.V1 | N501Y, 69–70del, P681H | Increased ~50% (NERVTAG) | Potentially 30% more lethal (NERVTAG) | Indications of ostensible reduced antigenic activity (ECDC) | Global | [2][3][4][5] |
Denmark | Oct 2020 | -- | Cluster 5, ΔFVI-spike (SSI) | Y453F, 69–70deltaHV | -- | -- | Moderately decreased sensitivity to neutralising antibodies (WHO) | Likely extinct | [6][7][8] |
South Africa | Dec 2020 | B.1.351 | 501.V2, 20H/501Y.V2, VOC-202012/02 | N501Y, K417N, E484K | Increased 50% (ECDC) | -- | 21% reduction in antigenicity, but effective neutralisation (ECDC) | Global | [2][9][10][3][11][12][13] |
Japan Brazil | Jan 2021 | P.1 | Descendant of B.1.1.28, VOC-202101/02 | N501Y, E484K, K417T | Likely increased (CDC) | -- | Overall reduction in effective neutralisation (ECDC) | Global | [10][14][15][16][13][3] |
United Kingdom Nigeria | Dec 2020 | B.1.525 | VUI-202102/03 (PHE), formerly UK1188 | E484K, F888L | -- | -- | 'Modestly' reduced neutralisation (COG-UK) | International | [17][18][19] |
PANGO lineages (cf. Nomenclature proposal, Nature) | Notes to PANGO lineages (cf. Alm et al.) | Nextstrain clades, 2021[21] | GISAID clades | Notable variants |
---|---|---|---|---|
A.1–A.6 | 19B | S | contains 'reference sequence' WIV04/2019[1] | |
B.3–B.7, B.9, B.10, B.13–B.16 | 19A | L | ||
O[a] | ||||
B.2 | V | |||
B.1 | B.1.5–B.1.72 | 20A | G | Lineage B.1 in the PANGO Lineages nomenclature system |
B.1.9, B.1.13, B.1.22, B.1.26, B.1.37 | GH | |||
B.1.3–B.1.66 | 20C | Includes CAL.20C[22] | ||
20G | Predominant in US generally, Jan '21[22] | |||
20H | Includes B.1.351 aka 20H/501Y.V2 or 501.V2 lineage | |||
B.1.1 | 20B | GR | Includes B.1.1.207 | |
20D | Includes P.1 and P.2[23] | |||
20F | ||||
20I | Includes lineage B.1.1.7 aka VOC-202012/01 or 20I/501Y.V1 | |||
B.1.177 | 20E (EU1)[21] | GV[a] | Derived from 20A[21] |
Bingo | Bonus Info |
---|